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15 -- People who take the weight-loss drug rimonabant may face heightened risks for severe depression and anxiety, Danish researchers report. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. 5 or 1 milligram of tesofensine was double that of weight loss seen with the currently available diet drugs Acomplia (rimonabant) or Meridia (sibutramine), the researchers said. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss.
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